Carboxy-PTIO Increases the Tetrahydrobiopterin Level in Mouse Brain Microvascular Endothelial Cells
نویسندگان
چکیده
منابع مشابه
Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells.
We examined the effect of the immunosuppressant, cyclosporin A (CsA) on the synthesis of tetrahydrobiopterin (BH4), a cofactor for nitric oxide (NO) synthase and a scavenger of reactive oxygen species (ROS), in mouse brain microvascular endothelial cells. Treatment with CsA increased the BH4 content and the expression of mRNA level of GTP cyclohydrolase I, the rate-limiting enzyme of BH4 synthe...
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Nitronyl nitroxides, such as derivatives of 2-phenyl4,4,5,5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIOs), react with NO to form the corresponding imino nitroxides (PTIs) and NO2. PTIOs are considered as monitors of NO, stoichiometric sources of NO2, biochemical and physiological effectors, specific tools for the elimination of NO, and potential therapeutic agents. However, a better understand...
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Fullerenols, water-soluble C60-fullerene derivatives, have been shown to exert neuroprotective effects in vitro and in vivo, most likely due to their capability to scavenge free radicals. However, little is known about the effects of fullerenols on the blood-brain barrier (BBB), especially on cerebral endothelial cells under inflammatory conditions. Here, we investigated whether the treatment o...
متن کاملHypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cells.
BACKGROUND AND PURPOSE Endoglin (CD105) is a membrane glycoprotein that is mutated in hereditary hemorrhagic telangiectasia (Osler-Rendu-Weber disease) and shows increased expression in proliferating endothelial cells during angiogenesis. METHODS We investigated the effect of hypoxia on endoglin expression in murine cerebral microvascular endothelial (bEND.3) cells in vitro and the possible i...
متن کاملHMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells.
OBJECTIVE Endothelial nitric oxide synthase (eNOS) activity is supported by tetrahydrobiopterin (BH4), which appears to be important for generating protective NO but decreases uncoupling formation of superoxide. We investigated the effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, in terms of BH4 metabolism in human umbilical vein endothelial cells (HUVECs). M...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 2001
ISSN: 0021-5198
DOI: 10.1254/jjp.87.51